No conclusive evidence is available. In the REMAKT trial, the treatment emergent adverse events (TEAE’s) in the conventional melatonin arm numbered five while the REMfresh® arm had none. All five TEAE’s were CNS or GI in nature. The Cmax in the conventional melatonin arm was more than 23 times the targeted maintenance threshold of 1000 pg/ml while the Cmax of REMfresh® was less than five times.

We suggest patients start with one 2 mg or 5 mg caplet of REMfresh® 30 to 90 minutes before their desired bedtime. You should instruct your patients to titrate up until they have achieved their desired results. Labeling suggests not to exceed 10 mg per night. REMfresh® can be taken with or without food. REMfresh® works best as part of a patient’s individualized Sleep Hygiene Cycle™. Everyone reacts differently to melatonin. A study done with a 2 mg prolonged release melatonin product in Europe shows it may take up to 3 weeks to allow a fuller effect of melatonin.

When patients take REMfresh®, they may feel ready for sleep within 30 minutes to an hour.† If they wake up in the middle of the night while taking REMfresh®, they may find it easier to fall back to sleep than with other melatonin products because of the unique release and absorption technology in REMfresh®^†. It is recommended that the patient take REMfresh® when they are aiming for a fuller night’s sleep. The active ingredient in REMfresh®, melatonin, is neutralized by your patient’s morning production of cortisol. REMfresh® is designed so patients wake up refreshed.^†

REMfresh® has no added gluten, nuts, shellfish, or dairy products.

No. REMfresh® is available without a prescription at select drug stores, grocery stores and on REMfresh.com and Amazon.com.

To receive office samples, please visit the following website

In clinical trials, melatonin supplements have not been shown to be habit-forming.

(European Medicines Agency. Assessment Report for Circadin;2007. www.ema.europa.eu/docs/en_GB/document_library/…/WC500026808.pdf. Accessed July 11, 2019).

REMfresh® is different from non-melatonin sleep products because it delivers the body’s own natural sleep ingredient, melatonin. Melatonin has not been shown to cause memory problems, morning dysfunction, drowsiness or unusual night occurrences such as sleepwalking. REMfresh® is non-habit forming and does not contain narcotics, hypnotics, barbiturates, sedatives, antihistamines, alcohol or other harsh additive chemicals.

No other melatonin product has been shown to have a 7-hour release and absorption profile. REMfresh®’s patented Ion-Powered Pump^™ delivery technology helps support deep and refreshing sleep throughout the night.^†

Like many supplements available today, REMfresh® isn’t covered by health insurance.